[Experimental study of the myelotoxic effect of tomizine].

Abstract

In tests conducted on 220 rats with transplantable sarcoma M-1 and intact animals acute toxicity, antineoplastic effect and the action on the blood system of tomizine, a new neoplastic drug of the group of the folic acid antagonists, were studied. Investigation involved a single intraperitoneal injection of the drug in DL50/30 and MTD. The compound is shown to exert an inhibiting action on the development of sarcoma M-1 and lengthens the survival of the tumour-stricken animals, without producing any pronounced myelotoxic effect. The disclosed shifts on the level of the periphedal blood and marrow were short-lived and concerned mainly the erythroid germ cells.

• Authors: E D Gol'dberg, V V Novitskiĭ, V M Plotnikov, L M Dalinger, V A Chernov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1979 Jan-Feb Vol. 42 Issue 1 Pg. 85-9 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K izucheniiu mielotoksicheskogo deĭstviia tomizina v éksperimente.
• PMID: 421896 (Publication Type: Journal Article)

Chemical References

• Folic Acid Antagonists
• Thiazines
• tomizine

Topics

• Anemia, Aplastic (chemically induced, pathology)
• Animals
• Bone Marrow (pathology)
• Folic Acid Antagonists (adverse effects, toxicity)
• Rats
• Sarcoma, Experimental (drug therapy)
• Thiazines (toxicity)
• Time Factors