Arachnoiditis from experimental myelography with aqueous contrast media.

Abstract

Myelography was performed on 80 monkeys to study postmyelographic arachnoiditis. Metrizamide myelography caused arachnoiditis when high concentrations were used, but not with the usual clinical concentrations. Arachnoiditis resulted after myelography with meglumine iocarmate; however, the risk of arachnoiditis was reduced by diluting the contrast medium. Prophylactic intrathecal methylprednisolone was not effective in preventing arachnoiditis. Blood in the cerebrospinal fluid did not affect the degree of arachnoiditis.

• Authors: V M Haughton, O P Eldevik, K C Ho, S J Larson, G F Unger
• Journal: Spine (Spine (Phila Pa 1976)) Vol. 3 Issue 1 Pg. 65-9 (Mar 1978) ISSN: 0362-2436 [Print] United States
• PMID: 417405 (Publication Type: Journal Article)

Chemical References

• Metrizamide
• Methylprednisolone
• Iothalamate Meglumine

Topics

• Animals
• Arachnoiditis (chemically induced, diagnostic imaging, prevention & control)
• Disease Models, Animal
• Haplorhini
• Iothalamate Meglumine (adverse effects)
• Methylprednisolone (therapeutic use)
• Metrizamide (adverse effects)
• Myelography (adverse effects)
• Spinal Diseases (chemically induced, diagnostic imaging)