Isoprenaline- and exercise- induced tachycardia in the assessment of beta-adrenoceptor blocking drugs; a comparison between tolamolol, practolol and propranolol.

Abstract

The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.

• Authors: K R Adam, L G Pullman, P C Scholfield
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 49 Issue 3 Pg. 560-3 (Nov 1973) ISSN: 0007-1188 [Print] England
• PMID: 4149697 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Benzamides
• Cresols
• Propanolamines
• Propranolol
• Isoproterenol
• Practolol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Benzamides (pharmacology)
• Cresols (pharmacology)
• Dogs
• Female
• Heart Rate (drug effects)
• Isoproterenol (pharmacology)
• Methods
• Physical Exertion
• Practolol (pharmacology)
• Propanolamines (pharmacology)
• Propranolol (pharmacology)
• Stimulation, Chemical