Distribution of concanavalin a receptors on normal rat liver cells and zajdela ascites hepatoma cells.

Abstract

The distribution of Concanavalin A receptors in cultures of normal rat liver cells and of Zajdela ascites hepatoma cells of the rat was investigated by the Con A-po technique (Bernhard and Avrameas, 1971). Con A-po labelling of the cell surface showed a patchy distribution of Concanavalin A receptors in ascites hepatoma cells, whereas continuous Con A-po labelling was seen at the surface of normal rat liver cells. The different distribution of Concanavalin A receptors was caused by rapid internalization of Con A-po labelled material and not by a simple rearrangement of the receptors. The significance of this process is discussed with respect to Concanavalin A receptor mobility and membrane stability after cell transformation.

• Authors: J Roth
• Journal: International journal of cancer (Int J Cancer) Vol. 14 Issue 6 Pg. 762-70 (Dec 15 1974) ISSN: 0020-7136 [Print] United States
• PMID: 4142787 (Publication Type: Journal Article)

Chemical References

• Culture Media
• Receptors, Drug
• Concanavalin A
• p-Dimethylaminoazobenzene
• Peroxidases

Topics

• Animals
• Carcinoma, Hepatocellular (metabolism, pathology)
• Cell Membrane (metabolism, ultrastructure)
• Cell Transformation, Neoplastic
• Cells, Cultured
• Concanavalin A (metabolism)
• Culture Media
• Golgi Apparatus (ultrastructure)
• Liver (metabolism, ultrastructure)
• Liver Neoplasms
• Microscopy, Electron
• Neoplasm Transplantation
• Neoplasms, Experimental
• Peroxidases
• Rats
• Receptors, Drug
• Staining and Labeling
• p-Dimethylaminoazobenzene