Lack of sequence homology among RNAs of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken endogenous RNA-directed DNA polymerase activity.

Abstract

The relatedness of the RNAs of the three avian systems, including six avian leukosis-sarcoma viruses, four reticuloendotheliosis viruses, and the microsome fraction of normal uninfected chicken embryo cells, containing RNA and a DNA polymerase have been studied by nucleic acid hybridization. All six avian leukosis-sarcoma viruses have closely related nucleotide sequences; and all four reticuloendotheliosis viruses have closely related nucleotide sequences. But, almost no similarities were detected between the RNAs of avian leukosis-sarcoma viruses and reticuloendotheliosis viruses. The RNA template of the endogenous RNA-directed DNA polymerase activity of normal uninfected chicken cells had no detectable relationship to RNAs of avian leukosis-sarcoma and reticuloendotheliosis viruses.

• Authors: C Y Kang, H M Temin
• Journal: Journal of virology (J Virol) Vol. 12 Issue 6 Pg. 1314-24 (Dec 1973) ISSN: 0022-538X [Print] United States
• PMID: 4128378 (Publication Type: Comparative Study, Journal Article)

Chemical References

• DNA, Viral
• Phosphorus Radioisotopes
• RNA, Viral
• Tritium
• RNA
• RNA-Directed DNA Polymerase

Topics

• Alpharetrovirus (analysis, enzymology, growth & development)
• Animals
• Base Sequence
• Birds
• Chick Embryo (analysis)
• Culture Techniques
• DNA, Viral (biosynthesis)
• Microsomes (analysis)
• Nucleic Acid Hybridization
• Phosphorus Radioisotopes
• RNA (analysis)
• RNA, Viral (analysis)
• RNA-Directed DNA Polymerase (metabolism)
• Rats
• Templates, Genetic
• Transcription, Genetic
• Tritium