Abstract |
Animal experiments have shown that malnutrition and protein deficiency states, respectively are associated with elevated tissue ribonuclease ( RNase, E.C. 3.1.4.22) activities. The causal intracellular alterations are unknown. Assuming that increased tissue RNase activities are reflected by serum levels, a study was made of the serum RNase activities in 10 healthy controls eating a normal diet (group I), 7 patients on long-term parenteral nutrition (group II), 13 chronic hemodialysis patients (group III), and 9 patients with acute pancreatitis (group IV). In group I the serum RNase activity corresponded to 195.3 + or -58.8 U/ml. A significant (p less than 0.005) elevation was noted in groups II (314.6 +/- 95.3 U/ml) and III (374.1 +/- 102.1 U/ml), no difference being detected in group IV (295.1 +/- 191.9 U/ml).
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Authors | H Sommer, V Gäng, A Heidland |
Journal | Klinische Wochenschrift
(Klin Wochenschr)
Vol. 55
Issue 20
Pg. 1019-20
(Oct 15 1977)
ISSN: 0023-2173 [Print] Germany |
PMID | 412011
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Blood Proteins
- Ribonucleases
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Blood Proteins
- Female
- Humans
- Kidney Failure, Chronic
(enzymology)
- Male
- Middle Aged
- Nutritional Physiological Phenomena
- Pancreatitis
(enzymology)
- Parenteral Nutrition
- Renal Dialysis
- Ribonucleases
(blood)
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