Allergic encephalomyelitis in monkeys induced by a peptide from the A1 protein.

Abstract

A major disease-inducing site for induction of experimental allergic encephalomyelitis in monkeys exists in Peptide P 14, the 37-residue segment of the A1 protein comprising its COOH-terminus. The peptide appears to contain the dominant encephalitogenic determinant, since it was as active as the A1 protein on a molar basis. By contrast, the 9-residue tryptophan region and the Peptide R region, active in guinea pigs and rabbits, respectively, were comparatively inactive in monkeys. The clinical and histologic expression of the disease produced by Peptide P 14 appeared identical to that induced by the intact A1 protein.

• Authors: E H Eylar, S Brostoff, J Jackson, H Carter
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 69 Issue 3 Pg. 617-9 (Mar 1972) ISSN: 0027-8424 [Print] United States
• PMID: 4111048 (Publication Type: Journal Article)

Chemical References

• Epitopes
• Peptides

Topics

• Amino Acid Sequence
• Animals
• Brain (pathology)
• Encephalomyelitis, Autoimmune, Experimental (immunology, pathology)
• Epitopes
• Haplorhini
• Molecular Weight
• Peptides (analysis)