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[Immunogenicity of L5178Y cells modified by different reagents].

Abstract
Lymphoma L5178Y cells were treated with neuraminidase of Vibrio cholerae, potassium iodine, dithiotreitol (DTT), mercaptoethanol, glutaraldehyde, iodoacetamide, merthiolate, sodium periodate, urea, papaine, trypsine and EDTA, to increase immunoreaction in tumor cells. Mice were immunized with modified tumor cells every week for one month. Thereafter non modified tumor cells were transplanted to previously immunized mice. Only the immunization with neuraminidase-treated cells rejected the tumor. Although the immunization with cells treated with potassium iodine, DTT and mercaptoethanol did not reject tumor, prolonged significantly span of life. The other reactives had neither effect on tumor rejection nor on span of life.
AuthorsH Gómez-Estrada, L M López-de la Rosa, G Becerril-Meza, J Arellano-Blanco, P Fernández-Quintero
JournalArchivos de investigacion medica (Arch Invest Med (Mex)) Vol. 8 Issue 2 Pg. 113-22 ( 1977) ISSN: 0066-6769 [Print] Mexico
Vernacular TitleInmunogenicidad del las células L5178Y modificadas con diferentes reactivos.
PMID410377 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Potassium Iodide
  • Mercaptoethanol
  • Urea
  • Neuraminidase
  • Glutaral
  • Dithiothreitol
  • Iodoacetamide
Topics
  • Animals
  • Antibody Formation
  • Dithiothreitol (pharmacology)
  • Glutaral (pharmacology)
  • Immunity, Cellular (drug effects)
  • Iodoacetamide (pharmacology)
  • Lymphoma (immunology)
  • Mercaptoethanol (pharmacology)
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms, Experimental
  • Neuraminidase (pharmacology)
  • Potassium Iodide (pharmacology)
  • Rats
  • Urea (pharmacology)

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