Abstract |
When adult male guinea pigs were injected unilaterally intratesticularly with compound 48/80 (1 mg in 0.05 ml saline), their testicular peritubular capillaries were engorged with blood, intratubular edema was present on the ipsilateral side, and the blood-testicular (BT) barrier (measured by the entrance of acriflavin into the seminiferous tubule) was ablated. The contralateral testis, when injected with saline, showed no pathological changes nor a breakdown of the BT barrier. Subcutaneous injection of guinea pigs with cadmium chloride resulted in a more intense intratubular fluorescence than was observed for 48/80-treated animals. The H1 and H2 receptor blockers ( diphenhydramine and cimetidine, respectively) reduced the intensity of capillary engorgement and edema. Intraperitoneal injections of 48/80 (0.5 mg) was lethal to rats, and both diphenhydramine and cimetidine induced survival even with as much as 1 mg of 48/80. Intratubular fluorescence was less severe than that observed for similarly treated guinea pigs or from cadmium chloride-treated rat testes. Neither treatment (48/80 or cadmium chloride) altered the blood-epididymal barrier of either guinea pigs or rats. Species differences were observed in the lethal effects of exogenously administered histamine.
|
Authors | B R Nemetallah, L C Ellis |
Journal | Archives of andrology
(Arch Androl)
Vol. 15
Issue 1
Pg. 41-8
( 1985)
ISSN: 0148-5016 [Print] England |
PMID | 4096574
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Receptors, Histamine H1
- Receptors, Histamine H2
- Cadmium
- Acriflavine
- p-Methoxy-N-methylphenethylamine
- Cimetidine
- Histamine
- Diphenhydramine
- Cadmium Chloride
|
Topics |
- Acriflavine
- Animals
- Blood-Testis Barrier
(drug effects)
- Cadmium
(pharmacology)
- Cadmium Chloride
- Cimetidine
(pharmacology)
- Diphenhydramine
(pharmacology)
- Guinea Pigs
- Histamine
(pharmacology)
- Male
- Microscopy, Fluorescence
- Rats
- Rats, Inbred Strains
- Receptors, Histamine H1
(drug effects)
- Receptors, Histamine H2
(drug effects)
- Testis
(cytology)
- p-Methoxy-N-methylphenethylamine
(pharmacology)
|