HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice.

Abstract
The antagonism of various components of maximal metrazol-seizures and the induction of ataxia have been studied in mice and rats by comparing Denzimol to 10 standard antiepileptic drugs. The data were analyzed by Cluster and Principal Components Analysis. Denzimol, phenytoin, carbamazepine and AD-810 showed an antagonistic effect on tonic but not on clonic seizures regardless of the animal species. Barbiturates, benzodiazepines and valproic acid, on the other hand, antagonized the whole pattern of metrazol-seizures. The selective activity of Denzimol and phenytoin against tonic seizures was also confirmed from literature data, which reported the activity of these compounds against bicuculline, thiosemicarbazide or picrotoxin induced convulsions.
AuthorsM Ibba, A Vanasia, R Testa
JournalPharmacological research communications (Pharmacol Res Commun) Vol. 17 Issue 12 Pg. 1169-80 (Dec 1985) ISSN: 0031-6989 [Print] United States
PMID4095125 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anticonvulsants
  • Imidazoles
  • denzimol
  • Pentylenetetrazole
Topics
  • Administration, Oral
  • Animals
  • Anticonvulsants (administration & dosage, therapeutic use)
  • Drug Interactions
  • Female
  • Imidazoles (administration & dosage, therapeutic use)
  • Injections, Intraperitoneal
  • Mice
  • Pentylenetetrazole
  • Rats
  • Rats, Inbred Strains
  • Seizures (chemically induced, drug therapy, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: