HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Interaction of histones with estrogens. Covalent adduct formation with 16 alpha-hydroxyestrone.

Abstract
Disturbed estrogen metabolism leading to increased 16 alpha-hydroxyestrone (16 alpha-OHE) has been described in patients with systemic lupus erythematosus and mammary carcinoma. Previous studies showed the formation of covalent complexes between 16 alpha-OHE and nonspecific cellular membrane proteins. The present study is concerned with the interaction of 16 alpha-OHE and histones. Covalent adduct formation between 16 alpha-OHE and individual histones was maximal with H1 histone. Other endogenous estrogens such as estrone, estradiol, and estriol did not interact with histones and form covalent adducts, nor did they interfere with the interaction of 16 alpha-OHE with these nuclear proteins. The evidence supports that the adduct formation between 16 alpha-OHE and histones proceeds via a stabilized Schiff base and subsequent rearrangement. This adduct formation which may have in vivo analogues may represent a mechanism for cellular transformation by this estrogen metabolite.
AuthorsS C Yu, J Fishman
JournalBiochemistry (Biochemistry) Vol. 24 Issue 27 Pg. 8017-21 (Dec 31 1985) ISSN: 0006-2960 [Print] United States
PMID4092052 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Estrogens
  • Histones
  • Hydroxyestrones
  • 16-hydroxyestrone
  • Estrone
  • Estradiol
Topics
  • Estradiol (metabolism)
  • Estrogens (metabolism)
  • Estrone (analogs & derivatives, metabolism)
  • Histones (metabolism)
  • Hydroxyestrones (metabolism)
  • Kinetics
  • Protein Binding
  • Thymus Gland

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: