Calcitonin treatment in hereditary bone dysplasia with hyperphosphatasemia: a radiographic and histologic study of bone.

Abstract

Two children with bone dysplasia with hyperphosphatasemia (juvenile Paget's disease) were treated with synthetic human calcitonin. The progress of bone disease was monitored radiographically and histologically. Pretreatment radiographs showed markedly abnormal bone, characterized by lack of discrete cortex and absence of normal modeling. During treatment a discrete cortex was formed composed of compact bone, and more normal modeling occurred. This coincided with a histologic change from woven bone before treatment to a more lamellar type during treatment.

• Authors: J P Whalen, M Horwith, L Krook, I MacIntyre, E Mena, F Viteri, B Torun, E A Nunez
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 129 Issue 1 Pg. 29-35 (Jul 1977) ISSN: 0361-803X [Print] United States
• PMID: 409139 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Calcitonin
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (blood)
• Calcitonin (therapeutic use)
• Child
• Child, Preschool
• Female
• Fibula (diagnostic imaging)
• Humans
• Hyperostosis, Cortical, Congenital (diagnostic imaging, drug therapy, genetics, pathology)
• Infant
• Leg (abnormalities)
• Male
• Osteocytes (physiology)
• Osteolysis (pathology)
• Radiography
• Syndrome
• Tibia (diagnostic imaging)