HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy].

Abstract
On the basis of a study of 156 patients the authors with the aid of a computer convened a dispersion analysis of interaction found in the process of treatment by conditional optimal doses of trimetin and succilep with 23 clinical parameters of the disease. It was established that on a statistically significant level the largest dose of trimetin (per 1 kg of body weight) was required in the treatment of myoclonic forms of seizures, with duration less that one year, pathological changes in the craniogram, signs of hypertension and the absence of prenatal noxious factors and pathology in the neurological state. The interaction of optimal doses of succilep with the cliniel characteristics is less expressed than for Trimetin and on a significant level is detected only for two of them: a larger dosage in longer duration of the disease and in the existence of prenatal noxious factors in the past history. It was established that with years the used amount of trimetin adn saccilep (per 1 kg of body weight) declines, while the therapeutical effectiveness does not drop.
AuthorsB V Iovlev, V P Kozlov, R A Kharitionov
JournalZhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 77 Issue 5 Pg. 750-3 ( 1977) ISSN: 0044-4588 [Print] Russia (Federation)
Vernacular TitleKolichestvennyÄ­ analiz uslovno-optimal'nykh doz suksilepa i trimetina pri lechenii malykh form épilepsii u deteÄ­ i podrostkov.
PMID409014 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Succinimides
  • Trimethadione
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Epilepsy, Absence (drug therapy)
  • Humans
  • Succinimides (administration & dosage, therapeutic use)
  • Trimethadione (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: