Acid and hyperosmolal solutions in the upper intestine of chronic gastric fistula rats inhibit gastric acid secretion by different mechanisms.

Abstract

In chronic gastric fistula rats 0.20 M HCl and 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) infused into a duodenal loop anastomosed to the jejunum (Roux-en-Y) produced maximal inhibition of pentagastrin-stimulated acid secretion, which amounted to 60% and 50%, respectively. In the present study in Roux-en-Y rats with gastric fistula, perfusion of the loop with hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl produced a greater reduction of the maximal response to pentagastrin (91% inhibition) than perfusion with 0.20 M HCl (64%), suggesting that HCl and hyperosmolal solution inhibit secretion by different mechanisms. The maximal acid response to histamine was more resistant to inhibition than that to pentagastrin; 0.20 M HCl inhibited secretion by 43%, 1200 mOsm X kg-1 of PEG solution by 42%, and hyperosmolal 0.20 M HCl by 60%. The results suggest that HCl and hyperosmolal solution also inhibit histamine-stimulated secretion by different mechanisms. The anatomical sites of the mechanisms remain to be established.

• Authors: C Wallin, S Emås, G Nylander
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 20 Issue 9 Pg. 1083-90 (Nov 1985) ISSN: 0036-5521 [Print] England
• PMID: 4089519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine Antagonists
• Polyethylene Glycols
• Histamine
• Pentagastrin
• Hydrochloric Acid

Topics

• Animals
• Dose-Response Relationship, Drug
• Gastric Acid (metabolism)
• Histamine (pharmacology)
• Histamine Antagonists (pharmacology)
• Hydrochloric Acid (pharmacology)
• Jejunum (drug effects)
• Male
• Pentagastrin (antagonists & inhibitors)
• Polyethylene Glycols (pharmacology)
• Rats
• Rats, Inbred Strains
• Secretory Rate (drug effects)
• Stomach (physiology)