HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Once per week oral administration of amiodarone in the prophylaxis of supraventricular paroxysmal tachycardia.

Abstract
In eight patients who had previously responded to treatment with oral amiodarone for prevention of recurrent supraventricular paroxysmal tachycardia, a new regimen of oral amiodarone dosing was evaluated. Each patient received the entire dose, previously taken throughout one week (600 to 1,200 mg), on a single day, once each week. After six weeks on this regimen, all patients were still free of arrhythmias and there were no adverse reactions to the drug. In the first week of the new treatment, amiodarone plasma levels gradually fell from 1.83 mg/l, to 0.48 mg/l, on average. The trough level was similar to that obtained when the drug was given on a daily basis. It is concluded that this new regimen can be used for patients receiving oral amiodarone, and it may be advantageous in improving the compliance of some patients.
AuthorsR Padrini, G Inama, D Piovan, F Furlanello
JournalPharmacological research communications (Pharmacol Res Commun) Vol. 17 Issue 11 Pg. 1043-52 (Nov 1985) ISSN: 0031-6989 [Print] United States
PMID4089009 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzofurans
  • desethylamiodarone
  • Amiodarone
Topics
  • Amiodarone (administration & dosage, analogs & derivatives, blood, therapeutic use)
  • Benzofurans (therapeutic use)
  • Female
  • Humans
  • Kinetics
  • Male
  • Tachycardia, Paroxysmal (prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: