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Studies on the effect of low dose methotrexate on rat adjuvant arthritis.

Abstract
Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 micrograms/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.
AuthorsW L Welles, J Silkworth, A L Oronsky, S S Kerwar, J Galivan
JournalThe Journal of rheumatology (J Rheumatol) Vol. 12 Issue 5 Pg. 904-6 (Oct 1985) ISSN: 0315-162X [Print] Canada
PMID4087270 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Methotrexate
Topics
  • Animals
  • Arthritis (drug therapy)
  • Arthritis, Experimental (drug therapy, etiology)
  • Drug Evaluation, Preclinical
  • Female
  • Inflammation (drug therapy, etiology)
  • Male
  • Methotrexate (administration & dosage)
  • Rats

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