Abstract |
Experiments were performed to assess the ability of bencianol (ZY15051) to reverse contractions of human basilar arteries in vitro that were induced by a wide range of substances implicated in the aetiology of migraine and cerebral arterial spasm. Bencianol caused a dose-related (1-100 micrograms ml-1) reversal of contractions induced by 5-hydroxytryptamine, noradrenaline, angiotensin II, prostaglandin F2 alpha, and U-46619 (a thromboxane-A2 mimetic). Bencianol was more effective against contractions induced by EC50 compared to maximal concentrations of each agent, and was least effective against the thromboxane-A2 mimetic, U-46619. In addition, contractions induced by thromboxane-A2-like substances generated from guinea-pig lungs were also reversed by bencianol but only at the highest concentration used (100 micrograms ml-1). The relevance of this action of bencianol to migraine and cerebral arterial spasm is discussed.
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Authors | E T Whalley, K S Paul, O P Gulati |
Journal | Cephalalgia : an international journal of headache
(Cephalalgia)
Vol. 5
Issue 4
Pg. 217-21
(Dec 1985)
ISSN: 0333-1024 [Print] England |
PMID | 4084977
(Publication Type: Journal Article)
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Chemical References |
- Flavonoids
- Vasodilator Agents
- bencianol
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Topics |
- Basilar Artery
(drug effects)
- Dose-Response Relationship, Drug
- Flavonoids
(therapeutic use)
- Humans
- Ischemic Attack, Transient
(drug therapy)
- Migraine Disorders
(drug therapy)
- Muscle, Smooth, Vascular
(drug effects)
- Vasodilator Agents
(therapeutic use)
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