Abstract |
The role of leukocyte transfusions in the prevention and treatment of infections in adults with granulocytopenia was investigated. Leukocytes were obtained from healthy volunteers by continuous-flow centrifugation. Histocompatibility antigen (HLA)-matched leukocytes were used to assess the prophylactic value of leukocyte transfusions. Seven patients with acute myelogenous leukemia received HLA-matched leukocytes during the period of maximal granulocytopenia associated with initial remission induction therapy; 20 concurrently treated patients who did not receive leukocyte transfusions were the control group. The patients receiving HLA-matched leukocytes had significantly fewer (P = 0.043) infectious episodes (not bacteriologically proven) during the study period, and remission occurred in 5 of the 7, compared with 10 of the 20 controls. In addition, 52 series of two or more ABO-compatible transfusions were given to 50 patients with proven infection or elevated temperature presumed due to infection and a granulocyte count of less than 0.5 X 10(9)/L. Response, indicated by a decrease in temperature, occurred in 23 patients. Leukocyte transfusions thus have an important adjuvant role in the management of patients with severe granulocytopenia.
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Authors | J E Curtis, R Hasselback, D E Bergsagel |
Journal | Canadian Medical Association journal
(Can Med Assoc J)
Vol. 117
Issue 4
Pg. 341-5
(Aug 20 1977)
ISSN: 0008-4409 [Print] Canada |
PMID | 407998
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Agranulocytosis
(complications, therapy)
- Blood Transfusion
- Female
- Humans
- Infection Control
- Infections
(therapy)
- Leukemia, Myeloid, Acute
(complications, therapy)
- Leukocyte Transfusion
- Male
- Middle Aged
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