[Therapeutic effect of dried ion exchange resin-treated human immunoglobulin (SM-4300) against severe bacterial and/or fungal infections in surgery].

Abstract

A newly developed human immunoglobulin for intravenous use, SM-4300, purified by cold ethanol precipitation and ion exchange resin, has been studied in the surgery. SM-4300 has been evaluated clinically against inpatients with severe bacterial and/or fungal infections in the combined use with the antibiotics which were resistant to antibiotic therapy. Total number of 13 patients affected with various severe infections were treated with SM-4300. Clinical effects of SM-4300 were excellent in 2 cases, good in 6, fair in 3 and poor in 2. The efficacy rate was summarized as 61.5%. No subjective and objective clinical side effects and abnormal laboratory findings were observed. In conclusion, combination therapy with SM-4300 and antibiotics was considered to be safe and effective against severe bacterial and/or fungal infections in the surgery.

• Authors: J Ota, N Ueda, Y Kimoto, Y Tsukahara, M Fujita, T Taguchi, T Okumura, K Tomita, M Kimura
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 9 Pg. 2638-46 (Sep 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4079029 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Immunoglobulins
• Ion Exchange Resins
• SM-4300

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Bacteria (immunology)
• Bacterial Infections (therapy)
• Child
• Drug Evaluation
• Drug Resistance, Microbial
• Drug Therapy, Combination
• Female
• Humans
• Immunization, Passive
• Immunoglobulins (administration & dosage)
• Ion Exchange Resins
• Male
• Middle Aged
• Mycoses (therapy)
• Postoperative Complications (therapy)
• Surgical Wound Infection (therapy)