[Clinical studies on the effectiveness of SM-4300, a new non-modified gammaglobulin preparation suitable for intravenous use, in refractory infections].

Abstract

Eighteen cases of various infections, mostly having severe underlying diseases and showing no or insufficient responses to antibacterial chemotherapy, were treated with additional intravenous drip infusion of SM-4300 (2.5 or 5 g, once a day, for 1-3 days). Eight of the cases were excluded from the assessment of the effectiveness, as they died too early, or as their fever was supposed to have been "tumor fever" retrospectively. SM-4300 was found to be effective in 2 out of 5 septicemia cases, in 3 pneumonia cases, including 1 complicated with septicemia, out of 4, and also in 1 patient with liver abscess, as well as in another of meningitis caused by Campylobacter fetus; i.e. the efficacy rate was estimated as 60% in total. Any side effects attributable to SM-4300 were observed in none of the 18 cases. These results obtained seem to endorse the usefulness of the preparation.

• Authors: Y Okamoto, K Maehara, K Mase, Y Iida, K Yasunaga, H Okubo, Y Ueda
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 9 Pg. 2515-25 (Sep 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4079018 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Immunoglobulins
• SM-4300

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Bacteria (immunology)
• Bacterial Infections (therapy)
• Drug Evaluation
• Drug Resistance, Microbial
• Drug Therapy, Combination
• Female
• Humans
• Immunization, Passive
• Immunoglobulins (administration & dosage)
• Infusions, Parenteral
• Male
• Middle Aged