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The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors.

Abstract
The antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6 X 12 mg/kg per week p.o. reduced the tumor area by 82% (control + 192%). D 15413 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse. In vitro, the growth of estrogen receptor positive MCF-7 breast cancer cells was inhibited by D 15413 (10(-8) - 10(-5) M). A mode of action considering endocrine and cytotoxic effects is discussed.
AuthorsE von Angerer, J Prekajac, M R Schneider, M R Berger
JournalJournal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 110 Issue 3 Pg. 216-20 ( 1985) ISSN: 0171-5216 [Print] Germany
PMID4077919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Estrogens
  • Indoles
  • D 15413
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Cell Line
  • Estrogens (pharmacology)
  • Indoles (pharmacology)
  • Mammary Neoplasms, Experimental (drug therapy)
  • Mice
  • Neoplasms, Hormone-Dependent (drug therapy)
  • Rats

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