[Comèl's ichthyosis linearis circumflexa: treatment with Ro 10-9359. Electron microscopic study].

Abstract

The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.

• Authors: C Mathys, G De Dobbeleer, M Ledoux, G Achten
• Journal: Dermatologica (Dermatologica) Vol. 171 Issue 4 Pg. 283-90 ( 1985) ISSN: 0011-9075 [Print] Switzerland
• Vernacular Title: Ichtyose linéaire circonflexe de Comèl: traitement par Ro 10-9359. Etude en microscopie électronique.
• PMID: 4076500 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etretinate

Topics

• Adult
• Etretinate (therapeutic use)
• Humans
• Ichthyosis (drug therapy, pathology)
• Male
• Microscopy, Electron
• Skin (ultrastructure)
• Syndrome