[Tridentate N-N-N chelating systems as potential antitumor agents].

Abstract

Tridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive.

• Authors: C Pellerano, L Savini, P Massarelli
• Journal: Il Farmaco; edizione scientifica (Farmaco Sci) Vol. 40 Issue 9 Pg. 645-54 (Sep 1985) ISSN: 0430-0920 [Print] Italy
• Vernacular Title: Sistemi chelanti tridentati N-N-N quali potenziali agenti antitumorali.
• PMID: 4076429 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Chelating Agents
• Hydrazones

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemical synthesis)
• Cell Line
• Chelating Agents (administration & dosage, chemical synthesis)
• Chemical Phenomena
• Chemistry
• Female
• Hydrazones (pharmacology)
• Leukemia P388 (drug therapy)
• Male
• Mice