HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pharmacokinetics of brodimoprim in serum and skin blister fluid.

Abstract
Following 400 mg brodimoprim given orally to 8 volunteers, the peaks of the mean concentration curves were 3.2 +/- 1.0 mg/l in serum and 1.0 +/- 0.2 mg/l (+/- SEM) in skin blister fluid. The terminal half-lives were 25.9 +/- 2.2 h and 42.2 +/- 6.5 h in serum and blister fluid, respectively. The area under the concentration-versus-time curve for blister fluid was 73% of serum value, and the mean recovery of bioactive drug in urine during 24 h was 3.4%. Considering the minimal inhibitory concentrations of potential target organisms and the slow elimination, the results suggest that brodimoprim may be useful in the treatment of infections, and that dosage once a day may be sufficient.
AuthorsT Kalager, A Digranes, A Salveson, T Bergan
JournalChemotherapy (Chemotherapy) Vol. 31 Issue 6 Pg. 405-9 ( 1985) ISSN: 0009-3157 [Print] Switzerland
PMID4075857 (Publication Type: Journal Article)
Chemical References
  • Trimethoprim
  • brodimoprim
Topics
  • Administration, Oral
  • Adult
  • Blister (metabolism)
  • Female
  • Humans
  • Kinetics
  • Male
  • Trimethoprim (administration & dosage, analogs & derivatives, blood, urine)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: