Abstract |
Following 400 mg brodimoprim given orally to 8 volunteers, the peaks of the mean concentration curves were 3.2 +/- 1.0 mg/l in serum and 1.0 +/- 0.2 mg/l (+/- SEM) in skin blister fluid. The terminal half-lives were 25.9 +/- 2.2 h and 42.2 +/- 6.5 h in serum and blister fluid, respectively. The area under the concentration-versus-time curve for blister fluid was 73% of serum value, and the mean recovery of bioactive drug in urine during 24 h was 3.4%. Considering the minimal inhibitory concentrations of potential target organisms and the slow elimination, the results suggest that brodimoprim may be useful in the treatment of infections, and that dosage once a day may be sufficient.
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Authors | T Kalager, A Digranes, A Salveson, T Bergan |
Journal | Chemotherapy
(Chemotherapy)
Vol. 31
Issue 6
Pg. 405-9
( 1985)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 4075857
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Adult
- Blister
(metabolism)
- Female
- Humans
- Kinetics
- Male
- Trimethoprim
(administration & dosage, analogs & derivatives, blood, urine)
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