Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon.

Abstract

Human adenovirus-12-transformed cells express greatly reduced levels of the major histocompatibility complex class I antigens and are highly tumorigenic in syngeneic hosts. The finding that expression of a transfected class I gene is sufficient to abrogate their tumorigenicity underscores the importance of defining the conditions that will lead to derepression of endogenous class I genes in these cells. Brief treatment of Ad12-transformed cells with interferon results in the rapid but transient expression of class I antigens, and these interferon-treated cells have significantly reduced tumorigenicity in immunocompetent hosts. We have further demonstrated that subcutaneous administration of interferon, subsequent to the introduction of a tumorigenic dose of Ad12-transformed cells, results in complete protection against this tumor. The ability of interferon to "induce" class I gene expression may be an important modality in the treatment of a variety of spontaneous tumors that exhibit greatly reduced levels of class I antigens on their cell surface.

• Authors: H Hayashi, K Tanaka, F Jay, G Khoury, G Jay
• Journal: Cell (Cell) Vol. 43 Issue 1 Pg. 263-7 (Nov 1985) ISSN: 0092-8674 [Print] United States
• PMID: 4075396 (Publication Type: Journal Article)

Chemical References

• H-2 Antigens
• Interferon Type I

Topics

• Adenoviruses, Human (physiology)
• Animals
• Cell Line
• Cell Membrane (immunology)
• Cell Transformation, Neoplastic
• Cell Transformation, Viral
• H-2 Antigens (genetics)
• Interferon Type I (pharmacology)
• Mice
• Mice, Inbred C3H
• Neoplasms, Experimental (etiology, immunology, pathology)
• Transfection