Induction of chromosomal aberrations and sister chromatid exchanges by propane sultone in human lymphocytes in vitro.

Abstract

Genotoxicological investigation of 1,3-propane sultone was undertaken using human lymphocyte cultures as the test system. Concentrations greater than 1 mM induced appreciable chromosomal aberrations, which increased proportionally to the dose or the duration of treatment. It was also observed that treatment administered at 45 degrees C produced almost 3 times more abnormal cells than at 37 degrees C. The chemical also produced a significantly higher frequency of SCEs.

• Authors: B L Kaul
• Journal: Toxicology letters (Toxicol Lett) Vol. 28 Issue 2-3 Pg. 139-42 (Nov 1985) ISSN: 0378-4274 [Print] Netherlands
• PMID: 4071562 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Mutagens
• Thiophenes
• 1,3-propane sultone

Topics

• Carcinogens
• Cells, Cultured
• Chromosome Aberrations
• Humans
• Lymphocytes (drug effects, ultrastructure)
• Mutagens
• Sister Chromatid Exchange (drug effects)
• Temperature
• Thiophenes (toxicity)