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Congenital acatalasemia: a study of neutrophil functions after provocation with hydrogen peroxide.

Abstract
Five Swiss subjects with hereditary acatalasemia (4 homo-, 1 heterozygous) were studied by a series of neutrophil function tests. H2O2 was added to a polymorphonuclear neutrophil leukocyte-suspension to produce a metabolic stress; neutrophil functions related to membrane deformation were subsequently found to be depressed, i.e., chemotaxis, membrane potential, and chemiluminescence. This mechanism might be one pathogenetic factor in the formation of mucosal ulcers in acatalasemic individuals.
AuthorsT Matsunaga, R Seger, P Höger, L Tiefenauer, W H Hitzig
JournalPediatric research (Pediatr Res) Vol. 19 Issue 11 Pg. 1187-90 (Nov 1985) ISSN: 0031-3998 [Print] United States
PMID4069828 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hydrogen Peroxide
  • Catalase
Topics
  • Adult
  • Catalase (blood)
  • Chemotaxis, Leukocyte (drug effects)
  • Humans
  • Hydrogen Peroxide (pharmacology)
  • In Vitro Techniques
  • Luminescent Measurements
  • Membrane Potentials (drug effects)
  • Metabolism, Inborn Errors (blood, complications)
  • Middle Aged
  • Neutrophils (drug effects, physiology)
  • Phagocytosis (drug effects)
  • Ulcer (etiology)

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