[Diagnostic use of the mathematical model of nonlinear regression in the interpretation of the crystalline bilirubin loading test in Gilbert's syndrome].

Abstract

The results of a study conducted both on subjects affected by constitutional hyperbilirubinaemia (Gilbert's syndrome) and healthy subjects using the charge test with crystalline bilirubin are presented. The parameters which are involved in bilirubin kinetics were established by means of non linear regression methods (the Marquardt method). 19 Gilbert syndrome patients and 12 normal control subjects were studied. Important parameters readily applicable to clinical and diagnostic evaluation of subjects suffering from familial cholemia were identified.

• Authors: V Alvisi, W Onofri, L Biasini, R Cappellari, M Massari, F Pavani, M Ruina, A D'Ambrosi
• Journal: Minerva medica (Minerva Med) Vol. 76 Issue 43 Pg. 2037-42 (Nov 10 1985) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Applicabilità diagnostica del modello matematico di regressione non lineare per l'interpretazione del test da carico con bilirubina cristallina nella sindrome di Gilbert.
• PMID: 4069415 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bilirubin

Topics

• Bilirubin (blood, metabolism)
• Gilbert Disease (diagnosis)
• Humans
• Hyperbilirubinemia, Hereditary (diagnosis)
• Kinetics
• Mathematics
• Models, Theoretical
• Regression Analysis