[Kinetics of the cell population of transplantable murine B-16 melanoma after administration of mercaptoundecahydrododecaborate enriched with 10B].

Abstract

The kinetics of DNA-synthesizing cells and melanocytes in the peripheral and central zones of transplantable B-16 mouse melanoma was studied by the cytometry and autoradiography methods at varying time after single administration of mercaptoundecahydrododecaborate saturated by 10B, a drug used for neutron capture therapy of malignant tumors. The drug was shown to induce proliferation and differentiation on the 1st day after injection (on the 8th day after transplantation). In the next 2 days proliferation did not change and differentiation was inhibited. The stimulation of proliferation and differentiation was more noticeable on tumor periphery, differentiation inhibition in tumor center.

• Authors: I P Shabalkin, R A Spryshkova, N G Serebriakov
• Journal: Meditsinskaia radiologiia (Med Radiol (Mosk)) Vol. 30 Issue 11 Pg. 32-4 (Nov 1985) ISSN: 0025-8334 [Print] Russia (Federation)
• Vernacular Title: Kinetika kletochnoĭ populiatsii perevivaemoĭ melanomy B-16 mysheĭ posle vvedeniia merkaptoundekagidrododekaborata, obogashchennogo po 10B.
• PMID: 4068942 (Publication Type: English Abstract, Journal Article)

Chemical References

• Borohydrides
• Isotopes
• Sulfhydryl Compounds
• mercaptoundecahydrododecaborate
• Boron

Topics

• Animals
• Borohydrides
• Boron
• Cell Division (drug effects)
• Isotopes
• Male
• Melanoma (pathology, radiotherapy)
• Mice
• Mice, Inbred C57BL
• Sulfhydryl Compounds (pharmacology)