[Effect of enkephalins on metabolic indices in experimental myocardial infarct in rats].

Abstract

An experimental study in rats demonstrated that myocardial infarction, induced by the ligation of the descending branch of the left coronary artery, led to marked metabolic disorders, such as increased lactate and glucose levels and decreased levels of blood calcium and magnesium and hepatic glycogen. A stable analogue of leu-enkephalin administered to the animals normalized metabolic parameters and improved the course of experimental myocardial infarction in rats.

• Authors: G K Zoloev, V D Slepushkin, M I Titov
• Journal: Kardiologiia (Kardiologiia) Vol. 25 Issue 8 Pg. 72-4 (Aug 1985) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Vliianie énkefalinov na metabolicheskie pokazateli pri éksperimental'nom infarkte miokarda u krys.
• PMID: 4068468 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Lactates
• Liver Glycogen
• Enkephalin, Leucine
• Enkephalin, Leucine-2-Alanine
• Magnesium
• Calcium
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Animals
• Blood Glucose (metabolism)
• Calcium (blood)
• Diuresis (drug effects)
• Enkephalin, Leucine (analogs & derivatives, therapeutic use)
• Enkephalin, Leucine-2-Alanine (analogs & derivatives)
• Lactates (blood)
• Liver Glycogen (metabolism)
• Magnesium (blood)
• Male
• Myocardial Infarction (drug therapy, metabolism)
• Rats