Abstract |
Eighteen infants and children with infectious diseases were treated with aspoxicillin (ASPC), a new semisynthetic penicillin. The result was as follows: The clinical responses to ASPC were excellent in 6 patients and good in 5 patients of 11 children with bacterial infections. The bacteria isolated from the culture of throat swab and urine in 5 patients were Streptococcus pneumoniae, Escherichia coli, and Staphylococcus aureus which were all eradicated by the treatment of ASPC. The mean serum concentration of ASPC reached the peaks of 73.3 micrograms/ml in 5 cases with dose of 20 mg/kg, and 136.3 micrograms/ml in 3 cases with dose of 40 mg/kg 15 minutes after the intravenous administration. The mean half-lives of ASPC in the serum were 1.08 hours for the dose of 20 mg/kg and 1.07 hours for the dose of 40 mg/kg. The mean urinary recoveries of ASPC in 6 hours following the intravenous administration were 73.7% in 3 cases with dose of 20 mg/kg, and 79.6% in 1 case with dose of 40 mg/kg. No clinical side effect of ASPC was observed. An increase of platelet was noticed in a child with infectious mononucleosis in the course of administration of ASPC.
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Authors | T Sato, K Ueda, T Kuroiwa |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 38
Issue 7
Pg. 1944-50
(Jul 1985)
ISSN: 0368-2781 [Print] Japan |
PMID | 4068227
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Amoxicillin
(adverse effects, analogs & derivatives, metabolism, therapeutic use)
- Bacterial Infections
(drug therapy, microbiology)
- Child
- Child, Preschool
- Drug Evaluation
- Female
- Humans
- Infant
- Male
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