[The therapeutic effects of aspoxicillin on various infectious diseases in children].

Abstract

Clinical application to ascertain the effects of aspoxicillin (ASPC), a new semisynthetic penicillin antibiotic, upon several infectious diseases of children was performed in 7 cases with pneumonia, 5 cases with acute bronchitis, each case with tonsillitis, enterocolitis, urinary tract infection and suspected sepsis. ASPC was injected by drip infusion and the dosage was 63-117 mg/kg/day in 3 and 4 times a day. Clinical efficacy obtained as "excellent" was in 7 cases, "good" in 8 cases "poor" in 1 case, and efficacy rate was 93.8%. From the bacteriological point of view, eliminated in each of H. influenzae, H. parainfluenzae, group A beta-Streptococcus and unchanged in a case of E. coli. There were transient thrombocytopenia in 2 cases and eosinophilia in 3 cases.

• Authors: H Wakiguchi, A Maeda, Y Ohara, Y Tone, K Araki, T Shiraishi, H Ogura, I Kitamura
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 7 Pg. 1925-30 (Jul 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4068226 (Publication Type: English Abstract, Journal Article)

Chemical References

• aspoxicillin
• Amoxicillin

Topics

• Adolescent
• Amoxicillin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Bacterial Infections (drug therapy, microbiology)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Hematologic Tests
• Humans
• Infant
• Infusions, Parenteral
• Kidney Function Tests
• Liver Function Tests
• Male