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Effect of prior treatment with thioglycolate on the incubation period of intraperitoneally injected scrapie.

Abstract
Injection of mice with thioglycolate 5 days prior to intraperitoneal injection of scrapie brain homogenate led to a statistically significant increase in scrapie incubation periods. This was seen with two different scrapie strains (ME7 and 139A), in different mouse strains (C57BL/6J and Compton White), and at several dilutions of the scrapie inoculum.
AuthorsR I Carp, S M Callahan
JournalIntervirology (Intervirology) Vol. 24 Issue 3 Pg. 170-3 ( 1985) ISSN: 0300-5526 [Print] Switzerland
PMID4066255 (Publication Type: Journal Article)
Chemical References
  • Thioglycolates
Topics
  • Animals
  • Ascitic Fluid (pathology)
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Phagocytes (drug effects)
  • Scrapie (drug therapy, etiology, pathology)
  • Species Specificity
  • Thioglycolates (pharmacology)
  • Time Factors

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