Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment.

Abstract

In a single-blind cross-over study the effect of oral treatment with pantethine on plasma and platelet lipid composition was evaluated in 20 patients with dyslipidaemia (7 IIa, 7 IIb and 6 Iv type). In plasma significant decreases of total cholesterol and triglycerides with increase of high density lipoprotein-cholesterol were observed. In platelets pantethine treatment significantly reduced phospholipid and cholesterol content. In addition gas-chromatographic analysis showed a reduction of saturated and monounsaturated and a relative increase of polyunsaturated fatty acid content of platelet phospholipids. A selective relative increase was observed of some n-3 polyunsaturated fatty acids like eicosapentaenoic and docosahexaenoic acid whereas arachidonic acid decreased. The present study indicates a favourable influence of pantethine not only on plasma but also on platelet lipids which could be of value in delaying the development of atherosclerosis in dyslipidaemic patients.

• Authors: G F Gensini, D Prisco, P G Rogasi, M Matucci, G G Neri Serneri
• Journal: International journal of clinical pharmacology research (Int J Clin Pharmacol Res) Vol. 5 Issue 5 Pg. 309-18 ( 1985) ISSN: 0251-1649 [Print] Switzerland
• PMID: 4066081 (Publication Type: Journal Article)

Chemical References

• Cholesterol, HDL
• Fatty Acids
• Phosphatidylcholines
• Phosphatidylethanolamines
• Phospholipids
• Sulfhydryl Compounds
• Triglycerides
• Pantetheine
• pantethine
• Cholesterol

Topics

• Administration, Oral
• Adult
• Aged
• Blood Platelets (analysis, drug effects)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Chromatography, Gas
• Fatty Acids (blood)
• Female
• Humans
• Hyperlipoproteinemia Type II (blood)
• Hyperlipoproteinemia Type IV (blood)
• Male
• Middle Aged
• Pantetheine (administration & dosage, analogs & derivatives, therapeutic use)
• Phosphatidylcholines (blood)
• Phosphatidylethanolamines (blood)
• Phospholipids (blood)
• Sulfhydryl Compounds (therapeutic use)
• Triglycerides (blood)