HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sepsis in the baboon: factors affecting resuscitation and pulmonary edema in animals resuscitated with Ringer's lactate versus Plasmanate.

Abstract
Septic shock and the formation of pulmonary edema were studied in 19 baboons. Four animals served as controls. Four were subjected to deep septic shock by infusion of live E. coli and then deliberately killed while in deep shock. Four were subjected to septic shock, resuscitated with Ringer's lactate (RL), and then killed 11/2 hours after resuscitation was started. Seven were subjected to shock and resuscitation attempted with Plasmanate (PL). Resuscitation with RL was successful for 11/2 hours in all four RL-animals. Resuscitation with PL was successful for 11/2 hours in three of the 7 PL-animals. There was an increased tendency for albumin to extravasate into the interstitium of the lungs after resuscitation. The amount of pulmonary edema, measured by both the thermodye technique and by analysis of post-mortem lung composition, was the same in animals resuscitated with RL and PL. Administration of pure colloid offers no protection to the lungs in resuscitating patients from septic shock.
AuthorsJ W Holcroft, D D Trunkey, M A Carpenter
JournalThe Journal of trauma (J Trauma) Vol. 17 Issue 8 Pg. 600-10 (Aug 1977) ISSN: 0022-5282 [Print] United States
PMID406417 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Blood Proteins
  • Isotonic Solutions
  • Lactates
  • Plasma Substitutes
Topics
  • Animals
  • Blood Proteins (therapeutic use)
  • Escherichia coli Infections (drug therapy)
  • Female
  • Haplorhini
  • Isotonic Solutions
  • Lactates (therapeutic use)
  • Papio
  • Plasma Substitutes (therapeutic use)
  • Pulmonary Edema (drug therapy, pathology, therapy)
  • Resuscitation
  • Shock, Septic (drug therapy, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: