The effect of dietary guar gum on the activities of some key enzymes of carbohydrate and lipid metabolism in mouse liver.
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| Abstract |
The effects of a 100 g/kg substitution of guar gum on the body-weight gain, food consumption and faecal dry weight of mice fed on a high-sucrose diet and on the activities of hepatic glucose-6-phosphate dehydrogenase (EC 1.1.1.49), 6-phosphogluconate dehydrogenase (EC 1.1.1.44), malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40), ATP-citrate (pro-3S)-lyase (EC 4.1.3.8), 6-phosphofructokinase (EC 2.7.1.11), pyruvate kinase (EC 2.7.1.40) and fructose-1, 6-bisphosphatase (EC 3.1.3.11) were studied. Guar gum had no effect on body-weight gain or food consumption but increased faecal dry weight. Guar gum increased the activities of glucose-6-phosphate dehydrogenase, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) and 6-phosphofructokinase expressed on a wet-liver-weight basis. Guar gum increased the activities of glucose-6-phosphate dehydrogenase, malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+), ATP-citrate (pro-3S)-lyase and 6-phosphofructokinase expressed on a liver-protein basis. Guar gum increased the activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) expressed on a body-weight basis. These results suggest that guar gum increases the flux through some pathways of hepatic lipogenesis when mice are fed on high-sucrose diets.
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| Authors | J C Stanley, E A Newsholme |
| Journal | The British journal of nutrition (Br J Nutr) Vol. 53 Issue 2 Pg. 215-22 (Mar 1985) ISSN: 0007-1145 [Print] England |
| PMID | 4063268 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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