Plasmapheresis in severe drug-induced toxic epidermal necrolysis.

Abstract	Five patients with severe drug-induced toxic epidermal necrolysis improved rapidly after one to two plasma exchanges. The improvement of all five patients treated with plasmapheresis contrasts with the disease's mortality rate of up to 50%, as reported in the literature and as observed among our previously treated patients. Since there is no effective treatment for toxic epidermal necrolysis, a controlled clinical trial to evaluate the effectiveness of plasma exchange would seem worthwhile.
Authors	D Kamanabroo, W Schmitz-Landgraf, B M Czarnetzki
Journal	Archives of dermatology (Arch Dermatol) Vol. 121 Issue 12 Pg. 1548-9 (Dec 1985) ISSN: 0003-987X [Print] United States
PMID	4062337 (Publication Type: Journal Article)
Chemical References	Pyrazoles Pyrazolones Sulfonamides Diclofenac pyrazolone
Topics	Adolescent Adult Aged Diclofenac (adverse effects) Female Humans Male Plasmapheresis Pyrazoles (adverse effects) Pyrazolones Stevens-Johnson Syndrome (etiology, therapy) Sulfonamides (adverse effects)

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