[Effect of mytilan--a polysaccharide from Crenomytilus grayanus--on local suppurative processes].

Abstract

The study on the effect of mytilan on the local suppurative processes caused by administration of a virulent staphylococcal culture to the mouse pad showed that this polysaccharide isolated from Crenomytilus grayanus had a pronounced antiexudative and antinecrotic effect. The positive results of the experiments may be explained by stimulation of the phagocytic activity of polymorphonuclear leukocytes and macrophages by mytilan which results in acceleration of the reparative processes in local staphylococcal infection. Hence, nonspecific stimulation of the defense mechanisms in local suppurative infection by mytilan and its antiexudative and antinecrotic effect are promising for investigation of the possibility of the mytilan clinical use.

• Authors: N F Krylova, R G Ovodova, N N Besednova, V E Glazkova, V I Molchanova
• Journal: Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology (Antibiot Med Biotekhnol) Vol. 30 Issue 8 Pg. 600-4 (Aug 1985) ISSN: 0233-7525 [Print] Russia (Federation)
• Vernacular Title: Vliianie mitilana--polisakharida iz Crenomytilus grayanus na mestnyĭ gnoĭnyĭ protsess.
• PMID: 4062278 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Polysaccharides
• mytilan

Topics

• Animals
• Anti-Infective Agents (therapeutic use)
• Drug Evaluation, Preclinical
• Immunity, Innate (drug effects)
• Mice
• Mice, Inbred CBA
• Phagocytosis (drug effects)
• Polysaccharides (therapeutic use)
• Staphylococcal Infections (drug therapy, immunology)
• Time Factors