Light and electron microscopic comparisons of cutaneous fibromas in white-tailed and mule deer.

Abstract

Cutaneous fibromas of white-tailed deer (Odocoileus virginianus), when compared with normal skin of the same species, had a thinner basement membrane; thickened stratum spinosum with numerous melanocytes, desmosomes, polyribosomes, and tonofilaments; focal hyperplasia of the stratum granulosum containing numerous large, electron-dense keratohyalin granules with irregular borders and containing occasional cells with diffuse intranuclear virus particles; and a moderately thickened stratum corneum with (although rarely) small crystalline arrays of virus particles. Normal mule deer (Odocoileus hemionus) skin was structurally similar to that of the white-tailed deer. Mule deer fibromas were similar to those in white-tailed deer, except for diffuse thickening of the stratum granulosum (the cells of which contained large keratohyalin granules of various electron densities with occasional composite granules) and except for a markedly thickened stratum corneum that contained numerous intranuclear viral inclusions. In negatively stained homogenates of tumors from both deer species, viral particles resembled papillomaviruses.

• Authors: J P Sundberg, D L Hill, E S Williams, S W Nielsen
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 46 Issue 10 Pg. 2200-6 (Oct 1985) ISSN: 0002-9645 [Print] United States
• PMID: 4062029 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Deer
• Female
• Fibroma (pathology, veterinary)
• Male
• Microscopy
• Microscopy, Electron
• Skin Neoplasms (pathology, veterinary)