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The action spectrum for benzanthrone photosensitization of mouse macrophages.

Abstract
An in vitro method for determination of the phototoxic action spectrum of benzanthrone was established using a cover slip-test tube culture system with mouse peritoneal macrophages. The action spectrum peaked between 380 and 400 nm with abrupt fall-off to either side. These findings correlate closely with both the absorption spectrum of benzanthrone and the clinical action spectrum of phototoxicity in humans.
AuthorsK J MacDonald, S A Walker, E M Walker, B E Johnson
JournalPhoto-dermatology (Photodermatol) Vol. 2 Issue 4 Pg. 237-40 (Aug 1985) ISSN: 0108-9684 [Print] Denmark
PMID4059079 (Publication Type: Journal Article)
Chemical References
  • Benz(a)Anthracenes
  • benzanthrone
Topics
  • Animals
  • Benz(a)Anthracenes (pharmacology)
  • Cell Survival (drug effects, radiation effects)
  • Dermatitis, Contact (etiology)
  • Humans
  • In Vitro Techniques
  • Macrophages (drug effects, radiation effects)
  • Mice
  • Mice, Inbred ICR
  • Photochemistry
  • Spectrophotometry

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