Abstract |
An in vitro method for determination of the phototoxic action spectrum of benzanthrone was established using a cover slip-test tube culture system with mouse peritoneal macrophages. The action spectrum peaked between 380 and 400 nm with abrupt fall-off to either side. These findings correlate closely with both the absorption spectrum of benzanthrone and the clinical action spectrum of phototoxicity in humans.
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Authors | K J MacDonald, S A Walker, E M Walker, B E Johnson |
Journal | Photo-dermatology
(Photodermatol)
Vol. 2
Issue 4
Pg. 237-40
(Aug 1985)
ISSN: 0108-9684 [Print] Denmark |
PMID | 4059079
(Publication Type: Journal Article)
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Chemical References |
- Benz(a)Anthracenes
- benzanthrone
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Topics |
- Animals
- Benz(a)Anthracenes
(pharmacology)
- Cell Survival
(drug effects, radiation effects)
- Dermatitis, Contact
(etiology)
- Humans
- In Vitro Techniques
- Macrophages
(drug effects, radiation effects)
- Mice
- Mice, Inbred ICR
- Photochemistry
- Spectrophotometry
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