Deregulation of immunoglobulin expression: is this the main cause of Burkitt's lymphoma?

Abstract

We here examine the role of c-myc in the aetiology of Burkitt's lymphomas. We suggest that c-myc causes cellular clones to become immortal while the deregulation of cell multiplication is the consequence of an altered production and/or structure of immunoglobulin chains caused by the 8-14, 8-2 or 8-22 translocations. Data relative to other immunoproliferative disorders are consistent with the hypothesis that the immunoglobulins play a key role in the regulation of the multiplication of lymphocytic cells.

• Authors: G Morpurgo
• Journal: Journal of theoretical biology (J Theor Biol) Vol. 116 Issue 3 Pg. 395-8 (Oct 07 1985) ISSN: 0022-5193 [Print] England
• PMID: 4058028 (Publication Type: Journal Article)

Chemical References

• Immunoglobulins

Topics

• Burkitt Lymphoma (etiology, immunology)
• Gene Expression Regulation
• Humans
• Immunoglobulins (genetics)
• Oncogenes
• Translocation, Genetic