HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Laminates composed of polypeptides and elastomers as a burn wound covering. Physicochemical properties.

Abstract
Laminates of synthetic polypeptides and elastomers, have been prepared, characterized and evaluated in terms of their application as a burn wound covering. It was found that the oxidation of L-methionine(Met)-containing polypeptide films by hydrogen peroxide led to an increase in the water vapour transmission rates (WVTR's) of the films. Elastomeric films had high WVTR's and good tensile properties for wound covering. The laminates composed of oxidized Met-containing copolypeptides and polyurethane had high WVTR's (790-1050 g X m-2 X day-1): for example, the laminate composed of an oxidized Met and N epsilon-benzyloxycarbonyl-L-lysine containing copolypeptide and polyurethane had high WVTR (960 g X m- X d-1) and large elongation (556%), also the cohesion between the two layers of this laminate was strong even after autoclaving. These characteristics seem to be very attractive for the possible application of laminates to wound covering. In addition the method of measuring WVTR is discussed.
AuthorsS Aiba, N Minoura, Y Fujiwara, S Yamada, T Nakagawa
JournalBiomaterials (Biomaterials) Vol. 6 Issue 5 Pg. 290-6 (Sep 1985) ISSN: 0142-9612 [Print] Netherlands
PMID4052544 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Peptides
  • Water
  • Oxygen
Topics
  • Amino Acids
  • Bandages
  • Burns (therapy)
  • Chemical Phenomena
  • Chemistry, Physical
  • Oxygen
  • Peptides
  • Permeability
  • Tensile Strength
  • Water

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: