HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Low dose of barbiturates for prevention of hippocampal lesions after brief ischemic episodes.

Abstract
Male Mongolian gerbils were subjected to bilateral carotid occlusion for 5 and 10 min, followed by 7 days of recirculation. After this interval, serial sections were made of the posterior region of the dorsal hippocampus, and the number of surviving neurons was determined per mm length of CA1 sector. In halothane-anesthetized animals only 21.1% of CA1 neurons survived 5-min ischemia, but this percentage could be raised to 78.6% when animals were pretreated with 25 mg/kg pentobarbital before ischemia. Pretreatment with 50 mg/kg pentobarbital before 5-min ischemia or pretreatment with 25 mg/kg pentobarbital before 10-min ischemia did not reduce CA1 lesions. It is concluded that a non-anesthetic dose of barbiturates is able to prevent selective vulnerability of CA1 sector, but that this effect is limited to the initial 5 min of ischemia.
AuthorsJ Hallmayer, K A Hossmann, G Mies
JournalActa neuropathologica (Acta Neuropathol) Vol. 68 Issue 1 Pg. 27-31 ( 1985) ISSN: 0001-6322 [Print] Germany
PMID4050352 (Publication Type: Journal Article)
Chemical References
  • Pentobarbital
Topics
  • Animals
  • Brain Ischemia (drug therapy, pathology)
  • Cell Survival
  • Gerbillinae
  • Hippocampus (blood supply, pathology)
  • Male
  • Pentobarbital (therapeutic use)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: