Abstract |
The objective of this study was to determine if 1,3-butanediol would reduce a neurologic deficit in rats exposed to ischemic- hypoxia (Levine rats). Age and weight matched male Sprague-Dawley rats were anesthetized with 2% halothane. The right common carotid and external jugular vein were ligated and cannulated and EEG screws were implanted followed by a 2 hour recovery period. Thirty minutes prior to exposure the rats received either 1,3-butanediol (47 mmole/kg i.v.; n = 11) or an equal volume of saline (n = 10). The rats were then exposed to 4.5% O2 until mean arterial blood pressure fell to 70 mm Hg. The oxygen level was then increased to 8% for 30 minutes, after which the rats were returned to room air. Posture, hemiparesis, circling, shuffling, activity, and ability to hang on to a vertical screen were scored 1 (normal) to 5 (severe deficit) at 2 and 20 hours after insult. The time to 70 mm Hg was extended from 7.9 +/- 0.9 min for saline treated rats to 19.0 +/- 2.3 min for the 1,3-butanediol treated rats (p less than 0.001). All eleven 1,3-butanediol treated rats survived the hypoxic insult; 90% (9/10) saline treated rats died. In an attempt to reduce the insult, six additional saline treated rats were switched to 8% O2 at 75 mm Hg and still 4/6 died. The mean score at 20 hours for three surviving saline treated rats was 3.4. A significantly better (p less than 0.002) mean 20 hour score for the surviving 8/11 1,3-butanediol treated rats was 1.2. 1,3-butanediol increases survival and decreases the neurologic deficits associated with this ischemic-hypoxic insult.
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Authors | E F Lundy, J Dykstra, B Luyckx, G B Zelenock, L G D'Alecy |
Journal | Stroke
(Stroke)
1985 Sep-Oct
Vol. 16
Issue 5
Pg. 855-60
ISSN: 0039-2499 [Print] United States |
PMID | 4049449
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Butylene Glycols
- 1,3-butylene glycol
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Topics |
- Acidosis
(physiopathology)
- Animals
- Brain
(physiopathology)
- Brain Ischemia
(physiopathology)
- Butylene Glycols
(pharmacology)
- Carotid Arteries
(surgery)
- Electroencephalography
- Hypoxia
(physiopathology)
- Jugular Veins
(surgery)
- Ketosis
(physiopathology)
- Ligation
- Male
- Neurologic Examination
- Rats
- Rats, Inbred Strains
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