[Acquired C1 esterase inhibitor deficiency and lymphoproliferative syndromes].

Abstract	About 20 cases of acquired C1 esterase inhibitor deficiency have been reported in association with malignant lymphomas. We describe 3 such patients. The 3 patients studied were asymptomatic and had low C1q level. Danazol administration resulted in an increase of C1 esterase inhibitor in 2 patients. The complement activation in acquired C1 esterase inhibitor deficiency could be explained by interaction with pathological cells of the spleen, the blood or the bone-marrow. The mechanism of decrease of C1 INH is discussed.
Authors	B Hory, J Panouse-Perrin, J L Dupond, R Leconte des Floris
Journal	La Revue de medecine interne (Rev Med Interne) Vol. 6 Issue 3 Pg. 266-71 (Jun 1985) ISSN: 0248-8663 [Print] France
Vernacular Title	Déficit acquis en inhibiteur de la C1 estérase et syndrome lymphoprolifératif.
PMID	4048687 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References	Complement C1 Inactivator Proteins Complement System Proteins Danazol
Topics	Aged Complement C1 Inactivator Proteins (deficiency) Complement System Proteins (analysis) Danazol (therapeutic use) Female Humans Lymphoproliferative Disorders (enzymology, immunology, therapy) Male Middle Aged Plasmapheresis Time Factors

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