Abstract |
The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations ( seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.
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Authors | O L Verstakova, L N Gerchikov, T A Gus'kova, S S Liberman, L A Chicherina |
Journal | Farmakologiia i toksikologiia
(Farmakol Toksikol)
1985 Jul-Aug
Vol. 48
Issue 4
Pg. 99-103
ISSN: 0014-8318 [Print] Russia (Federation) |
Vernacular Title | Toksikologicheskoe izuchenie otechestvennogo tetratsiklicheskogo antidepressanta inkazana. |
PMID | 4043371
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Antidepressive Agents
- Blood Glucose
- Carbolines
- metralindole
- Imipramine
- Epinephrine
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Topics |
- Animals
- Antidepressive Agents
(poisoning, toxicity)
- Blood Cells
(drug effects)
- Blood Glucose
(analysis)
- Carbolines
(poisoning, toxicity)
- Dogs
- Dose-Response Relationship, Drug
- Drug Synergism
- Epinephrine
(toxicity)
- Female
- Imipramine
(toxicity)
- Lethal Dose 50
- Male
- Mice
- Rabbits
- Rats
- Time Factors
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