[Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine].

Abstract

The derivatives of GABA and beta-phenylethylamine (PEA) the tranquilizer phenibut and muscle relaxant baclofen (p-chloro-beta-phenyl-GABA, lioresal) diminished all studied effect of PEA in mice, namely seizures, sedation, excitation, hyperthermia. Diazepam diminished only seizures whereas haloperidol excitation and hyperthermia. PEA injections anatogonized (the sedative and hypothermic effects of phenibut and diazepam and the anticonvulsant (against l-kynurenine) effect of phenibut and baclofen. The role of antagonism to PEA in the mechanism of the antianxiety effect of tranquilizers is discussed.

• Authors: I P Lapin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1985 Jul-Aug Vol. 48 Issue 4 Pg. 50-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Razlichiia i skhodstvo vo vzaimodeĭstviia fenibuta, baklofena i diazepam s fenilétilaminom.
• PMID: 4043364 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Phenethylamines
• Tranquilizing Agents
• gamma-Aminobutyric Acid
• Baclofen
• Diazepam
• 4-amino-3-phenylbutyric acid

Topics

• Animals
• Baclofen (pharmacology)
• Body Temperature (drug effects)
• Diazepam (pharmacology)
• Dose-Response Relationship, Drug
• Drug Interactions
• Male
• Mice
• Orientation (drug effects)
• Phenethylamines (pharmacology)
• Seizures (chemically induced, drug therapy)
• Structure-Activity Relationship
• Time Factors
• Tranquilizing Agents (pharmacology)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)