HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Activity of titanocene dihalides against a human colon carcinoma heterotransplanted to athymic mice.

Abstract
The antitumor activity of cis-diamminedichloroplatinum (II) and of two metallocene derivatives, titanocene dichloride (C5H5)2TiCl2 and titanocene dibromide (C5H5)2TiBr2, was investigated against a human colon adenocarcinoma heterotransplanted to athymic mice. The substances were administered at various doses on a Q2DX5 or a Q3DX5 schedule. Whereas cis-diamminedichloroplatinum (II) induced an only marginal tumor-inhibiting effect, both titanocenes markedly suppressed tumor development (T/C values: 23-40%) and caused stagnation and relative decrease of tumor growth, when they were applied in subtoxic doses far below the LD10 level. The results are remarkable with respect to the general insensitivity of human colorectal carcinomas to cytostatic agents.
AuthorsP Köpf-Maier, A Moormann, H Köpf
JournalEuropean journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 21 Issue 7 Pg. 853-7 (Jul 1985) ISSN: 0277-5379 [Print] England
PMID4043173 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Organometallic Compounds
  • titanocene dibromide
  • Titanium
  • titanocene dichloride
  • Cisplatin
Topics
  • Adenocarcinoma (drug therapy)
  • Animals
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Cisplatin (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Organometallic Compounds (administration & dosage, therapeutic use)
  • Sigmoid Neoplasms (drug therapy)
  • Titanium (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: