[Study of the mechanism of the anti-hypoxic action of lithium oxybutyrate using cerebral ischemia as a model].

Abstract

A study was made of energy metabolism and concentration of malonic dialdehyde (MDA) in cerebral tissue of mice given sodium hydroxybutyrate and lithium hydroxybutyrate 30 and 60 s after decapitation. Administration of lithium hydroxybutyrate brought about a more economic consumption of the glycogen pool as compared with "hypoxic" control. The differences were revealed in the action of both salts on ATP. The concentration of MDA declined after their administration, lithium hydroxybutyrate being more efficacious. The possible mechanisms of the action of lithium hydroxybutyrate are discussed.

• Authors: I A Ivanova, Iu G Bobkov, A S Losev
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 100 Issue 9 Pg. 319-22 (Sep 1985) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Izuchenie mekhanizma antigipoksicheskogo deĭstviia oksibutirata litiia na modeli ishemii mozga.
• PMID: 4041599 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hydroxybutyrates
• Organometallic Compounds
• Malondialdehyde
• lithium hydroxybutyrate
• Sodium Oxybate
• Lithium

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (drug therapy, metabolism)
• Energy Metabolism (drug effects)
• Hydroxybutyrates (therapeutic use)
• Lithium (therapeutic use)
• Male
• Malondialdehyde (metabolism)
• Mice
• Organometallic Compounds
• Sodium Oxybate (therapeutic use)