Parathyroid hormone-like bioactivity in a patient with severe osteitis fibrosa cystica due to malignancy: renotropic actions of a tumour extract as assessed by cytochemical bioassay.

Abstract

A patient is described with malignancy, hypercalcaemia and radiological evidence of severe parathyroid bone disease but undetectable concentrations of circulating immunoreactive PTH. Autopsy showed the tumour to be a metastatic bronchial carcinoid with no evidence of primary parathyroid disease. Extracts of the tumour had no PTH immunoreactivity but had high concentrations of a substance with identical activity to PTH in a cytochemical bioassay. The biological activity of the extract was not inhibited by PTH antibodies but was inhibited by an antagonist to PTH bioactivity.

• Authors: N Loveridge, G N Kent, D A Heath, E L Jones
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 22 Issue 2 Pg. 135-46 (Feb 1985) ISSN: 0300-0664 [Print] England
• PMID: 4039233 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Parathyroid Hormone
• Tissue Extracts

Topics

• Aged
• Animals
• Bronchial Neoplasms (metabolism, secondary)
• Carcinoid Tumor (metabolism, secondary)
• Female
• Histocytochemistry
• Humans
• Kidney (metabolism)
• Mice
• Mice, Inbred BALB C
• Osteitis Fibrosa Cystica (etiology, metabolism)
• Parathyroid Hormone (antagonists & inhibitors, metabolism)
• Radioimmunoassay
• Tissue Extracts (metabolism)